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Date Published: 30/03/2022
Abstract Views: 800
Views PDF: 205
Issue
Vol. 1 No. 1 (2022)
Section
SCIENCE OF MEDICAL AND PHARMACEUTICAL
How to Cite
Nguyen, T. H., Nguyen, T. V. P., Dang, T. X. Q., Vo, V. L., Nguyen, V. K., Vo, T. B. H., & Ma, C. T. (2022). Investigation of microscopic characteristics, preliminary chemical constituents and cytotoxicity activity on cancer cell lines of Rhizoma Stachydis affinis. Dong A University Journal of Science, 1(1), 57-66. https://js.donga.edu.vn/index.php/daujs/article/view/7

Investigation of microscopic characteristics, preliminary chemical constituents and cytotoxicity activity on cancer cell lines of Rhizoma Stachydis affinis

Nguyen Thanh Hoang1, Nguyen Thi Vy Phuong2, Dang Thi Xuan Quyen2, Vo Van Leo1, Nguyen Viet Kinh1, Vo Thi Bach Hue3, Ma Chi Thanh1
1 Faculty of Pharmacy, University of Medicine and Pharmacy
2 Tipharco Pharmaceutical Joint Stock Company
3 Faculty of Pharmacy, Lac Hong University

Main Article Content

Abstract

The rhizoma Stachydis affinis is used as a food as well as a medicinal herb in traditional medicine to treat infections, colds and pneumonia. In this study, we carried out morphological analysis, preliminary survey of chemical composition and tested the cytotoxic activity of this rhizome. The morphological characteristics had been clarified, and this information will contribute to the standardization of herbal ingredients for the production of safe pharmaceutical products of natural origin. Preliminary investigation results showed that this rhizome contains carotenoid compounds, essential oils, triterpenoids, coumarins, proanthocyanidins, polyphenols, and polyuronics. At a concentration of 100 μg/mL, the extracts were capable of causing moderate toxicity to lung cancer MDA-MB-231, liver cancer Hep3B and cervical cancer Hela cell lines. The results of this study contribute to the correct identification of this rhizome in Vietnam by the morphology characteristics, and provide important information on the medicinal ingredients as well as the activity against some cancer cell lines

Article Details

Keywords

Rhizoma Stachys affinis, stachyose, morphology, cytotoxicity

References

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