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Date Published:
30/03/2022
Abstract Views: 1477
Views PDF: 1108
Views PDF: 1108
Issue
Section
SCIENCE OF MEDICAL AND PHARMACEUTICAL
How to Cite
Lam, T. D. N., Duong, V. T., Vo, T. T. H., Le, P. Q. T., Quach, N. T. U., Nguyen, T. D. L., & Nguyen, T. N. C. (2022). Study on chemical constituents of coffee husks collected in Gia Lai (Coffea canephora Pierre ex A.Froehner, Rubiaceae). Dong A University Journal of Science, 1(1), 49-56. https://js.donga.edu.vn/index.php/daujs/article/view/6
Study on chemical constituents of coffee husks collected in Gia Lai (Coffea canephora Pierre ex A.Froehner, Rubiaceae)
Main Article Content
Abstract
Coffee husks are the major residues from the processing of coffee that should be reused to bring more financial value and reduce environmental problem. This study is carried out to isolate the components from the coffee husks Coffea canephora P. collected in Gia Lai aiming to use as medicinal material. Preliminary phytochemical survey, extraction, seperation, isolation and purification were done as routine work. Ethanol 50% extract showed strong antioxidant activity in comparison with ethanol 96% and 70% extracts. Five compounds were isolated and their chemical structure were identified as β-sitosterol, ethyl caffeate, caffeine, daucosterol and (+)-catechin basing on spectroscopic methods (NMR, MS) and comparison with literatures. These results are the premise for future studies to evaluate the bioactivities of coffee husks.
Article Details
Keywords
Coffee husk, Coffea canephora, caffein, catechin, antioxidant activity
References
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Zottich, U., Da Cunha, M., Carvalho, A. O., Dias, G. B., Silva, N. C. M., Santos, I. S., do Nacimento, V. V, Miguel, E. C., Machado, O. L. T., & Gomes, V. M. Purification, biochemical characterization and antifungal activity of a new lipid transfer protein (LTP) from Coffea canephora seeds with α-amylase inhibitor properties. Biochimica et Biophysica Acta (BBA) - General Subjects, 1810(4), 375-383, 2011.
Aderogba, M. A., McGaw, L. J., Bezabih, M., & Abegaz, B. M. Isolation and characterisation of novel antioxidant constituents of Croton zambesicus leaf extract. Natural Product Research, 25(13), 1224-1233, 2011.
Bùi, Anh Võ. & Nguyễn, Đ. L. Nghiên cứu thu nhận pectin từ vỏ cà phê. Science & Technology Development, 13. No.K2-, 46-56, 2009.
Chiang, Y. M., Lo, C. P., Chen, Y. P., Wang, S. Y., Yang, N. S., Kuo, Y. H., & Shyur, L. F. Ethyl caffeate suppresses NF‐ κB activation an its ownstream inf ammatory me iators, iNOS, COX‐ 2, and PGE2in vitro or in mouse skin. British Journal of Pharmacology, 146(3), 352-363, 2005.
International Coffee Organization. Coffee prices rise in July after three months of decline. Coffee Market Report, 8:4(July), 2020.
Duangjai, A., Ontawong, A., & Saokaew, S. Possible Anti-Diabetic Potentials of Coffea arabica L. and Their Active Compounds on Inhibition of Alpha-Amylase and Alpha-Glucosidase Activities. Gut & Liver, 13, 2019.
Galanakis, C. M. (Ed. ). Handbook of coffee processing by-products: sustainable applications. Academic Press, 2017.
Hà T.T.H., Nguyễn T.P., Phạm G.N., Hoàng V.H., Trịnh D.T, N. M. K. & P. T. T. Các phenolic phân lập từ phần trên mặt đất cây Phong quỳ Sa Pa. Tạp chí Dược Liệu, 22(4), 195-199, 2017.
Hu, G. L., Gao, Y., Peng, X. R., Liu, J. H., Su, H. G., Huang, Y. J., & Qiu, M. H. Lactam ent-Kaurane diterpene: A new class of diterpenoids present in roasted beans of coffea arabica. Journal of Agricultural and Food Chemistry, 68(22), 6112-6121, 2020.
Hye, M. A., Taher, M. A., Ali, M. Y., Ali, M. U., & Zaman, S. Isolation of (+)-catechin from Acacia catechu (Cutch Tree) by a convenient method. Journal of Scientific Research, 1(2), 300-305, 2009.
Kieu Tran, T. M., Kirkman, T., Nguyen, M., & Van Vuong, Q. Effects of drying on physical properties, phenolic compounds and antioxidant capacity of Robusta wet coffee pulp (Coffea canephora). Heliyon, 6(7), e04498, 2020.
Lee, H. N., Kim, J.-K., Kim, J. H., Lee, S.-J., Ahn, E.-K., Oh, J. S., & Seo, D.-W. A mechanistic study on the anticancer activity of ethyl caffeate in human ovarian cancer SKOV-3 cells. Chemico-Biological Interactions, 219, 151-158, 2014.
Mander, L., & Liu, H. W. Comprehensive natural products II: chemistry and biology (Vol. 1). Elsevier, 2010.
Montagnana, M., Favaloro, E. J., & Lippi, G. Coffee intake and cardiovascular disease: virtue does not take center stage. Seminars in Thrombosis and Hemostasis, 38(02), 164-177, 2012.
Ndhlala, A. R., Moyo, M., & Van Staden, J. Natural Antioxidants: Fascinating or Mythical Biomolecules? Molecules, 15(10), 6905-6930, 2010.
Ramirez-Coronel, M. A., Marnet, N., Kolli, V. K., Roussos, S., Guyot, S., & Augur, C. Characterization and estimation of proanthocyanidins and other pheno ics in coffee pulp (Coffea arabica) y thiolysis− high-performance liquid chromatography. Journal of Agricultural and Food Chemistry, 52(5), 1344-1349, 2004.
Institute of Medicine (US) Committee on Military Nutrition Research. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. In Nutrition Today, 37(1), 2002.
Stevens, P. F. RUBIACETOACE Jussieu, nom. Cons. Angiosperm Phylogeny, 2001.
Suzuki, A., Yamamoto, N., Jokura, H., Yamamoto, M., Fujii, A., Tokimitsu, I., & Saito, I. Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats. Journal of Hypertension, 24(6), 1065-1073, 2006.
Tsuchiya, H. Stereospecificity in membrane effects of catechins. Chemico-Biological Interactions, 134(1), 41-54, 2001.
Viet, P. D., Doan, D. L. N., Thi, S. D., & Van, T. P. Sản xuất ethanol sinh học từ vỏ quả cà phê. Tạp chí Khoa học Trường Đại học Cần Thơ, 55(CĐ Công nghệ Sinh học), 212-217, 2019.
Wang, J., Gu, S. S., Pang, N., Wang, F. Q., Pang, F., Cui, H. S., ... & Wu, F. A. Alkyl caffeates improve the antioxidant activity, antitumor property and oxidation stability of edible oil. PloS One, 9(4), e95909, 2014.
Xiang, M., Su, H., Hu, J., & Yunjun, Y. Isolation, identification and determination of methyl caffeate, ethyl caffeate and other phenolic compounds from Polygonum amplexicaule var. sinense. Journal of Medicinal Plants Research, 5, 1685-1691, 2011.
Mitrev, Y., Gerginova, D., & Simova, S. Nuclear Magnetic Resonance Spectroscopy Techniques | Carbon-13. Encyclopedia, 459-471, 2019.
Zottich, U., Da Cunha, M., Carvalho, A. O., Dias, G. B., Silva, N. C. M., Santos, I. S., do Nacimento, V. V, Miguel, E. C., Machado, O. L. T., & Gomes, V. M. Purification, biochemical characterization and antifungal activity of a new lipid transfer protein (LTP) from Coffea canephora seeds with α-amylase inhibitor properties. Biochimica et Biophysica Acta (BBA) - General Subjects, 1810(4), 375-383, 2011.