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Porous Microspheres: A Review of Synthesis Protocols, Physicochemical Characterization, and Multidisciplinary Applications
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Abstract
Significant attention is currently focused on porous microspheres within material science due to their extensive utility in sectors ranging from pharmaceuticals to environmental remediation. These spherical entities are distinguished by specific structural attributes, including high surface-to-volume ratios, tunable pore dimensions, and adaptable morphologies. This review presents a detailed examination of the primary materials used in their fabrication, along with an evaluation of established and emerging synthesis strategies. Although porous microspheres have been extensively reviewed within isolated disciplines, a comprehensive framework linking advanced, scalable fabrication techniques to cross-disciplinary applications is rarely presented. Therefore, a specific gap in the current literature is addressed by this review through the systematic correlation of emerging synthesis strategies, such as microfluidics and 3D printing, with their consequential impacts on structural tunability and multidisciplinary functionality. New perspectives on the transition from traditional bench-top synthesis to sustainable, large-scale production are contributed. In this manuscript, the synergistic roles played by organic, inorganic, and hybrid matrices in enhancing material stability are critically analyzed. Furthermore, the efficacy of modern preparation methodologies is assessed against traditional techniques, and essential characterization protocols are highlighted. Finally, the transformative deployment of these advanced microspheres in drug delivery, catalysis, and biosensing is explored, and critical bottlenecks associated with cost-efficiency and industrial scalability are discussed.
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Keywords
Porous microspheres, Synthesis protocols, Physicochemical characterizations, Drug delivery systems, Environmental remediation
References
Abdullah, A., Zumra, Z., & Ahmed, S. (2025). Recent innovations in nanocomposite beads for the removal of pollutants from water: a critical review. Environmental Science: Water Research & Technology.
Bai, H., Yu, D., & Du, X. (2025). Review of porous microspheres for enzyme immobilization: strategies, applications, and prospects. International Journal of Biological Macromolecules, 139627.
Bai, Y., Liu, F., Zhang, Y., Wu, L., Liu, H., & Ba, Y. (2025). Fabrication of Poly (lactic acid) Microspheres with Various Micro-Structure by Microfluidic T-junction and Gelatin Pore-forming Agent. BioResources, 20(4).
Bhalala, K., Jadeja, D., & Dudhat, K. (2025). Microspheres: preparation methods, advances, applications, and challenges in drug delivery. Biomedical Materials & Devices, 1–40.
Cai, Y., Chen, Y., Hong, X., Liu, Z., & Yuan, W. (2013). Porous microsphere and its applications. International Journal of Nanomedicine, 1111–1120.
Cao, Q., Chen, J., Zhang, Z., Xiong, Y., Ma, J., Sun, W., Chen, X., Lou, Q., Kaijia, T., & Lin, F. (2025). Faster Efficacy and Reduced Nodule Occurrence with Porous PLLA (Poly-L-Lactic Acid) Porous Microspheres. Frontiers in Bioengineering and Biotechnology, 13, 1571820.
Desoky, A. A., Ereiba, K. T., Bakr, A. M., & Abdraboh, A. S. (2025). Enhancement of bioactivity and molecular docking analysis of bioglass loaded zein and sodium alginate composite beads for biomedical applications. Scientific Reports, 15(1), 13460.
Ding, J., Cheng, Z., Ma, Y., Zhang, T., Du, L., Jiang, X., Zhu, M., Li, W., & Xu, B. (2025). Engineering injectable and highly interconnected porous silk fibroin microspheres for tissue regeneration. Advanced Healthcare Materials, 14(2), 2402932.
Dou, Y., Zhang, X., Chen, G., Jiang, X., Li, X., & Yu, L. (2025). A controllable self-template synthesis strategy for hierarchical porous carbon microspheres with cavity structures for supercapacitor applications. Journal of Alloys and Compounds, 1010, 177107.
Gonzalez, M. F., Ruseckaite, R. A., & Cuadrado, T. R. (1999). Structural changes of polylactic‐acid (PLA) microspheres under hydrolytic degradation. Journal of Applied Polymer Science, 71(8), 1223–1230.
Guo, T., Luo, L., Wang, L., Zhang, F., Liu, Y., & Leng, J. (2025). Smart Polymer Microspheres: Preparation, Microstructures, Stimuli-Responsive Properties, and Applications. ACS Nano, 19(19), 18003–18036.
Gurung, B. D., & Kakar, S. (2020). An overview on microspheres. Int J Health Clin Res, 3(1), 11–24.
He, J., Qiao, L., Fu, Q., Zhang, X., Liu, J., Li, S., & Hu, X. (2025). Synergistic integration of bio-mineralized nanoparticles and porous microsphere scaffolds for dual bioactive delivery in bone regeneration. Journal of Controlled Release, 386, 114097.
Huang, Y., Zhu, X., Zhou, J., Li, H., Zhang, W., Shen, D., Huang, Z., Zhang, T., Zhuang, L., & Qin, L. (2025). Hydrogel Microspheres for Biomedical Applications. Small Science, e202500453.
Hyon, S. H. (2000). Biodegradable poly (lactic acid) microspheres for drug delivery systems. Yonsei Medical Journal, 41(6), 720–734.
Jing, Y.-Y., Li, Y.-C., Luo, Y.-Q., Zou, L.-H., Tang, Y.-M., Lin, Y.-X., & Meng, F.-B. (2025). Effects of gum incorporation on the properties of sodium alginate-based composite hydrogel beads for encapsulating lactic acid bacteria. Carbohydrate Polymers, 124298.
Kang, Y., Wang, L., Wang, Y., Zhang, H., Wang, Y., Hong, D., Qv, Y., & Wang, S. (2013). Construction and enhanced gas sensing performances of CuO-modified α-Fe2O3 hybrid hollow spheres. Sensors and Actuators, B: Chemical, 177, 570–576.
Lee, J., & Patel, R. (2022). Wastewater treatment by polymeric microspheres: a review. Polymers, 14(9), 1890.
Li, G., Wu, J., Qi, X., Wan, X., Liu, Y., Chen, Y., & Xu, L. (2022). Molecularly imprinted polypyrrole film-coated poly (3, 4-ethylenedioxythiophene): polystyrene sulfonate-functionalized black phosphorene for the selective and robust detection of norfloxacin. Materials Today Chemistry, 26, 101043.
Li, H., Yu, L., Li, Z., Li, S., Liu, Y., Qu, G., Chen, K., Huang, L., Li, Z., & Ren, J. (2025). A Narrative Review of Bioactive Hydrogel Microspheres: Ingredients, Modifications, Fabrications, Biological Functions, and Applications. Small, 21(25), 2500426.
Li, Q., Liu, Y., Li, G., Han, Q., Lin, H., Yu, S., Zhang, Y., & Liu, F. (2025). Mixed matrix microspheres for improving storage quality of red blood cells via removing lactate metabolites. Separation and Purification Technology, 363, 132004.
Li, X., Li, L., Wang, D., Zhang, J., Yi, K., Su, Y., Luo, J., Deng, X., & Deng, F. (2024). Fabrication of polymeric microspheres for biomedical applications. Materials Horizons, 11(12), 2820–2855.
Ma, C. M., Chen, Y., & Kuan, H. (2006). Polystyrene nanocomposite materials—preparation, mechanical, electrical and thermal properties, and morphology. Journal of Applied Polymer Science, 100(1), 508–515.
Maciejewska, M. (2025). A View on the Synthesis and Characterization of Porous Microspheres Containing Pyrrolidone Units. Materials, 18(11), 2432.
Moulay, S. (2018). Functionalized polystyrene and polystyrene-containing material platforms for various applications. Polymer-Plastics Technology and Engineering, 57(11), 1045–1092.
Sankeshi, S., Bajaj, P., Sivasankaran, V. P., Sunkara, M. V, & Basak, P. (2025). Hierarchical Self-Assembly of SnO2 Nanoparticles into Porous Microspheres: Exceptionally Selective Ammonia Sensing at Ambient. ACS Applied Materials & Interfaces, 17(2), 3757–3771.
Shi, X.-D., Sun, P.-J., & Gan, Z.-H. (2018). Preparation of porous polylactide microspheres and their application in tissue engineering. Chinese Journal of Polymer Science, 36(6), 712–719.
Sivakumar, M., Muthu, Y., & Elumalai, K. (2025). Advancements in drug delivery systems: a focus on microsphere-based targeted delivery. Biomedical Materials & Devices, 3(2), 1030–1057.
Sun, J., Zhou, Q., Wei, Z., & Xue, C. (2025). Multifunctional intelligent indication labels featuring antibacterial properties based on pectin/carboxymethyl chitosan incorporated with porous microspheres loaded with anthocyanins: A new approach for salmon preservation and freshness detection. Food Hydrocolloids, 158, 110571.
Tuo, K., Li, J., Li, Y., Liang, C., Shao, C., Hou, W., Fan, C., Li, Z., Pu, S., & Chen, Z. (2025). Phytic Acid Functionalized Hierarchical Porous Metal‐Organic Framework Microspheres for Efficient Extraction of Uranium from Seawater. Small, 21(2), 2407272.
Vindhyasarumi, A., Saritha, A., Sethulekshmi, A. S., & Joseph, K. (2025). Advancements in carbon microsphere-based nanocomposites: synthesis, properties and multifaceted applications: a comprehensive review. Carbon Letters, 35(2), 387–416.
Wang, H., Fang, M., Shi, T., Zhai, L., & Tang, C. (2006). Preparation of porous poly (lactic acid)/SiO2 hybrid microspheres. Journal of Applied Polymer Science, 102(1), 679–683.
Wang, T., Li, J., Li, J., Sun, Y., Liu, Y., Guo, Y., An, C., Wang, J., & Wu, B. (2025). Controlled preparation of hollow n-al/Fe2O3 MICs microspheres by two-droplet microfluidic technique and performance study. Ceramics International.
Wu, Z., Shi, G., Li, L., Piao, Z., Wang, J., Chen, R., Hao, Z., Zhang, Z., Li, Z., & Huang, Y. (2025). Recent advances in smart responsive hydrogel microspheres for tissue regeneration: preparation, characteristics and applications. Materials Horizons, 12(21), 8943–8988.
Yang, S., Wu, H., Peng, C., He, J., Pu, Z., Lin, Z., Wang, J., Hu, Y., Su, Q., & Zhou, B. (2024). From the microspheres to scaffolds: Advances in polymer microsphere scaffolds for bone regeneration applications. Biomaterials Translational, 5(3), 274.
Zeng, C., Zhao, H., Zhang, L., & Yu, L. (2025). Continuous and rapid preparation of urea-formaldehyde resin microspheres with adjustable sizes and structures in a microchannel reactor. Chemical Engineering and Processing-Process Intensification, 209, 110184.
Zhang, J., Zhou, Y., Li, C., & Wang, Z. (2024). Advancements in solid-state hydrogen storage: A review on the glass microspheres. Langmuir, 40(20), 10433–10448.
Zhang, X., Zhang, X., Liu, D., Wang, L., Wen, G., Wang, Y., & Huang, X. (2024). Advances in carbon microsphere-based nanomaterials for efficient electromagnetic wave absorption. Langmuir, 40(36), 18857–18881.
Zhang, Y., Nawi, M. A. A., Shaari, R., & Hassan, A. (2025). Enhancing Drug Efficacy: A Review of Research Progress in Drug-Loaded Microspheres. Cureus, 17(8).
Zhao, D., Zhou, N., Wu, C., Wu, B., Chen, F., Zhang, A., & Chen, K. (2025). The application of chitin materials in enzymatic catalysis: A review. Carbohydrate Polymers, 352, 123172.