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Prevalence of Intestinal Bacteria Resistant to Carbapenem Antibiotics at Hospital 199.
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Abstract
Background: Carbapenem antibiotic is a group of broad-spectrum antibiotics used in the treatment of severe infections or multidrug-resistant bacteria. However, Carbapenem resistance has appeared and spread strongly globally, especially in the group of intestinal Gram-negative bacilli (Carbapenem Resistant Enterobacteriaceae) (CRE). This study aims to analyze the prevalence and factors related to CRE infections in the rectum of inpatients at the hospital. Subjects and methods: Cross-sectional descriptive study was conducted on 271 inpatients undergoing CRE screening at 8 clinical departments from 2022-2024. Results: The patients with CRE colonization was 31.4% (85/271), of which in the Emergency Resuscitation Department it was 44.7% (38/85). The two main CRE strains isolated were Klebsiella pneumonia accounting for 72.9% and Escherichia coli accounting for 37.6%, and 10.5% (9/85) of patients were co-infected with both K. pneumoniae and E. coli. Factors related to CRE prevalence include patients admitted to the intensive care unit, pre-hospital antibiotic treatment, diagnosed infection, surgical intervention in treatment, and antibiotic use. produce carbapenems and Quinolone/Fluoroquinolone and have a diagnosis/suspension of hospital infections. Conclusion: CRE prevalence in inpatients is quite high. Hospitals need to have appropriate measures such as improving infection control management to contribute to limiting harmful factors to prevent this colonization.
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Keywords
CRE, Antibiotic resistant bacteria, Carbapenem resistance and associated factors
References
Chen, X., Wen, X., Jiang, Z., & Yan, Q. (2023). Prevalence and factors associated with carbapenem-resistant Enterobacterales (CRE) infection among hematological malignancies patients with CRE intestinal colonization. Ann Clin Microbiol Antimicrob, 22(1), 3. doi:10.1186/s12941-023-00554-6
Gomides, M. D. A., Fontes, A. M. S., Silveira, A., Matoso, D. C., Ferreira, A. L., & Sadoyama, G. (2022). The importance of active surveillance of carbapenem-resistant Enterobacterales (CRE) in colonization rates in critically ill patients. PLoS One, 17(1), e0262554. doi:10.1371/journal.pone.0262554
Giannella, M., Trecarichi, E. M., De Rosa, F. G., Del Bono, V., Bassetti, M., Lewis, R. E., . . . Tumbarello, M. (2014). Risk factors for carbapenem-resistant Klebsiella pneumoniae bloodstream infection among rectal carriers: a prospective observational multicentre study. Clin Microbiol Infect, 20(12), 1357-1362. doi:10.1111/1469-0691.12747
Hưng, T. T. M. (2022). Thực trạng kháng kháng sinh của một số vi khuẩn thường gặp ở cộng đồng và một số yếu tố liên quan ở Việt Nam NĂM 2018-2019. Luận án Tiến sĩ Y tế công cộng.
Nguyễn Quang Toàn, N. T. K. P., Bùi Tiến Sỹ, Lê Thị Hằng, Bùi Thị Châu LiNH, Nguyễn Thị Nghiên, Nguyễn Văn Trọng. (2022). Đánh giá kết quả sàng lọc vi khuẩn đường ruột kháng carbapenem tại các đơn vị điều trị tích cực, Bệnh viện Trung ương Quân Đội 108 Tạp chí Y dược lâm sàng 108.
Perez, F., Pultz, M. J., Endimiani, A., Bonomo, R. A., & Donskey, C. J. (2011). Effect of antibiotic treatment on establishment and elimination of intestinal colonization by KPC-producing Klebsiella pneumoniae in mice. Antimicrob Agents Chemother, 55(6), 2585-2589. doi:10.1128/aac.00891-10
Salomão, M. C., Freire, M. P., Boszczowski, I., Raymundo, S. F., Guedes, A. R., & Levin, A. S. (2020). Increased Risk for Carbapenem-Resistant Enterobacteriaceae Colonization in Intensive Care Units after Hospitalization in Emergency Department. Emerg Infect Dis, 26(6), 1156-1163. doi:10.3201/eid2606.190965
Sharma, K., Tak, V., Nag, V., Bhatia, P., & Nikhil, K. (2023). An observational study on carbapenem-resistant Enterobacterales (CRE) colonisation and subsequent risk of infection in an adult intensive care unit (ICU) at a tertiary care hospital in India. Infection Prevention in Practice, 5, 100312. doi:10.1016/j.infpip.2023.100312
Suwantarat, N., & Carroll, K. C. (2016). Epidemiology and molecular characterization of multidrug-resistant Gram-negative bacteria in Southeast Asia. Antimicrob Resist Infect Control, 5, 15. doi:10.1186/s13756-016-0115-6
Tischendorf, J., de Avila, R. A., & Safdar, N. (2016). Risk of infection following colonization with carbapenem-resistant Enterobactericeae: A systematic review. Am J Infect Control, 44(5), 539-543. doi:10.1016/j.ajic.2015.12.005
Tran, D. M., Larsson, M., Olson, L., Hoang, N. T. B., Le, N. K., Khu, D. T. K., . . . Hanberger, H. (2019). High prevalence of colonisation with carbapenem-resistant Enterobacteriaceae among patients admitted to Vietnamese hospitals: Risk factors and burden of disease. J Infect, 79(2), 115-122. doi:10.1016/j.jinf.2019.05.013
van Loon, K., Voor In 't Holt, A. F., & Vos, M. C. (2018). A Systematic Review and Meta-analyses of the Clinical Epidemiology of Carbapenem-Resistant Enterobacteriaceae. Antimicrob Agents Chemother, 62(1). doi:10.1128/aac.01730-17
Võ Trần Trọng Bình, H. M. T., Phạm Thị Vân Phương (2021). Tỷ lệ người bệnh bị chiếm cư trực khuẩn gram âm đường ruột kháng carbapenem và các yếu tố liên quan tại bệnh viện Đại học Y dược Thành phố Hồ Chí Minh. Y học Thành phố Hồ Chí Minh, Tập 25 số 2, 29-34.
Yamamoto, N., Asada, R., Kawahara, R., Hagiya, H., Akeda, Y., Shanmugakani, R. K., . . . Tomono, K. (2017). Prevalence of, and risk factors for carriage of carbapenem-resistant Enterobacteriaceae among hospitalized patients in Japan. Journal of Hospital Infection, 97. doi:10.1016/j.jhin.2017.07.015
Yuan, W., Xu, J., Guo, L., Chen, Y., Gu, J., Zhang, H., . . . Deng, D. (2022). Clinical Risk Factors and Microbiological and Intestinal Characteristics of Carbapenemase-Producing Enterobacteriaceae Colonization and Subsequent Infection. Microbiol Spectr, 10(6), e0190621. doi:10.1128/spectrum.01906-21