Analyse Serum Immunoglobulin E (IgE) Level of Acute and Chronic Urticaria Patients Visiting Danang Dermato-Venereology Hospital in 2021
Main Article Content
Abstract
Urticaria is a quite common skin disorder that can affect 15 - 25 % of the world population. Pathogenesis of this disease is the result of a complex chain reaction, in which the role of immnunoglobulin E (IgE) is the most important. The increase of IgE quantity in patients shows many different applications. In this study, using descriptive cross-study analysis, we examined 36 allergens (including 35 allergens and total IgE) on 147 patients visiting Danang Dermato-Venereology Hospital, after that we analyzed the level of special IgE in serum of patients with acute and chronic urticaria, investigated the correlation between IgE level and severity of urticaria. The results showed that moderate and high antiallergic concentrations were found to be higher than low and very high levels of allergenic inducers. However, the total IgE concentration in serum of urticaria patients is not compatible with the degree of disease activity. Therefore, clarifying the relationship between IgE levels and expression levels of urticaria disease will open up effective solutions for treatment of urticaria patients in the future, to improve the quality of life of patients.
Article Details
Keywords
patient, allergen, IgE, urticaria, serum
References
Colgecen, E., Ozyurt, K., Gul, A. I., & Utas, S. 2015. Evaluation of etiological factors in patients with chronic urticaria. Acta Dermatovenerologica Croatica, 23(1), 36-42.
Doong J.C, Chichester K, Oliver E.T, et al. 2017. Chronic idiopathic urticaria: systemic complaints and their relationship with disease and immune measures, J Allergy Clin Immunol Pract Epub ahead of print doi, doi: 10.1016/j.jaip. 2016.11.037.
Gao X.Y., Han Y, Yao X. 2019. Elevated Serum Total IgE Levels in Patients with Chronic Urticaria Indicate Insensitivity to Antihistamine Treatment, International Journal of Dermatology and Venereology, 2-3.
Hay, R. J., Johns, N. E., Williams, H. C., Bolliger, I. W., Dellavalle, R. P., Margolis, D. J., Marks, R., Naldi, L., Weinstock, M. A., Wulf, S. K., Michaud, C., J.l. Murray, C., & Naghavi, M. 2014. The global burden of skin disease in 2010: An analysis of the prevalence and impact of skin conditions. Journal of Investigative Dermatology, 134(6), 1527-1534. https://doi.org/10.1038/jid.2013.446
Hennino, A., Bérard, F., Guillot, I., Saad, N., Rozières, A., & Nicolas, J. F. 2006. Pathophysiology of urticaria. Clinical Reviews in Allergy & Immunology, 30(1), 3-11. https://doi.org/https://doi.org/10.1385/CRIAI:30:1:003
Konstantinou G.N., Asero R, Maurer M, et al. 2009. EAACI/GA(2)LEN task force consensus report: the autologous serum skin test in urticarial, Allergy, 64:1256-1268.
Lapi, F., Cassano, N., Pegoraro, V., Cataldo, N., Heiman, F., Cricelli, I., Levi, M., Colombo, D., Zagni, E., Cricelli, C., & Vena, G. A. 2016. Epidemiology of chronic spontaneous urticaria: Results from a nationwide, population-based study in Italy. British Journal of Dermatology, 174(5), 996-1004. https://doi.org/10.1111/bjd.14470
Spoerl, D., Nigolian, H., Czarnetzki, C., & Harr, T. 2017. Reclassifying anaphylaxis to neuromuscular blocking agents based on the presumed Patho-Mechanism: IgE-Mediated, pharmacological adverse reaction or “innate hypersensitivity”? International Journal of Molecular Sciences, 18(6), 1-14. https://doi.org/10.3390/ijms18061223
Vu, T. Q., Thuong, N. Van, My, L. H., & Doanh, L. H. 2019. Correlation between total serum IgE level and disease activity in chronic urticaria. 29(29), 15-20.
Williams, Kelli W., and H. P. S. 2015. Anaphylaxis and urticaria. Immunology and Allergy Clinics, 35(01), 199-219.
Zelić S.B, Rubeša G, Brajac I, et al. 2016. Satisfaction with life and coping skills in the acute and chronic urticaria, Psychiatr Danub 28: 3438.
Zuberbier, T., Aberer, W., Asero, R., Bindslev-Jensen, C., Brzoza, Z., Canonica, G. W., Church, M. K., Ensina, L. F., Giménez-Arnau, A., Godse, K., Gonçalo, M., Grattan, C., Hebert, J., Hide, M., Kaplan, A., Kapp, A., Abdul Latiff, A. H., Mathelier-Fusade, P., Metz, M., … Maurer, M. 2014. The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: The 2013 revision and update. Allergy: European Journal of Allergy and Clinical Immunology, 69(7), 868-887. https://doi.org/10.1111/all.12313