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26/06/2024
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Nguyễn, T. K., Phạm, T. K. H., Nguyễn, T. H. V., Lê, B. N., & Nguyễn, N. L. (2024). Molecular Docking Approach to Identify Flavonoids as Potential Phosphodiesterase 5 Inhibitors for Erectile Dysfunction Treatment. Tạp chí Khoa học Đại học Đông Á, 3(2). https://doi.org/10.59907/daujs.3.2.2024.283
Molecular Docking Approach to Identify Flavonoids as Potential Phosphodiesterase 5 Inhibitors for Erectile Dysfunction Treatment
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Tóm tắt
An erection that is not strong enough for sexual activity might be caused by erectile dysfunction. Periodically experiencing difficulties achieving an erection is not always a reason for alarm. On the other hand, if erectile dysfunction persists, it may lead to stress, undermine confidence, and exacerbate interpersonal issues. In addition to being a risk factor for heart disease, difficulties achieving or maintaining an erection may also indicate an underlying medical issue that needs to be treated. Many studies have also steadily examined flavonoids' capacity to inhibit the phosphodiesterase 5 enzyme in several recent studies. This is an enzyme expressed in erectile tissue that is the most important substance that degrades cGMP in the body's smooth muscle cells. This study identified two prominent flavonoids that had inhibitory effects on the phosphodiesterase 5 enzyme: Amenoflavone and Umbralisib. Our research suggests new molecular pathways by which these substances might influence biological processes. One compound that shows promise for treating erectile dysfunction and is safe for healthy cells is Amentoflavone.
Chi tiết bài viết
Từ khóa
Erectile dysfunction, Phosphodiesterase 5, virtual screening, molecular docking
Tài liệu tham khảo
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Cosconati, S., Forli, S., Perryman, A. L., Harris, R., Goodsell, D. S., & Olson, A. J. (2010). Virtual screening with AutoDock: theory and practice. Expert opinion on drug discovery, 5(6), 597-607. https://doi.org/https://doi.org/10.1517/17460441.2010.484460
Christensen, B. S., Grønbæk, M., Osler, M., Pedersen, B. V., Graugaard, C., & Frisch, M. (2011). Associations between physical and mental health problems and sexual dysfunctions in sexually active Danes. The journal of sexual medicine, 8(7), 1890-1902. https://doi.org/https://doi.org/10.1111/j.1743-6109.2010.02145.x
Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Scientific reports, 7(1), 42717. https://doi.org/https://doi.org/10.1038/srep42717
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Elena, B. W., Zachary, M., Haritha, P., Graham, B. A., & Wayne, H. J. (2023). Current status of intracavernosal injection therapy in erectile dysfunction. Expert Opinion on Pharmacotherapy, 24(8), 925-933. https://doi.org/https://doi.org/10.1080/14656566.2023.2204189
Ferguson III, J. E., & Carson III, C. C. (2013). Phosphodiesterase type 5 inhibitors as a treatment for erectile dysfunction: Current information and new horizons. Arab Journal of Urology, 11(3), 222-229. https://doi.org/https://doi.org/10.1016/j.aju.2013.07.009
Francis, S. H., & Corbin, J. D. (2005). Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction. Expert opinion on drug metabolism & toxicology, 1(2), 283-293. https://doi.org/https://doi.org/10.1517/17425255.1.2.283
Ghofrani, H. A., Osterloh, I. H., & Grimminger, F. (2006). Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nature reviews Drug discovery, 5(8), 689-702. https://doi.org/https://doi.org/10.1038/nrd2030
Gu, S. j., Li, M., Yuan, Y. m., Xin, Z. c., & Guan, R. l. (2021). A novel flavonoid derivative of icariside II improves erectile dysfunction in a rat model of cavernous nerve injury. Andrology, 9(6), 1893-1901. https://doi.org/https://doi.org/10.1111/andr.13065
Giuliano, F., Denys, P., & Joussain, C. (2023). Safety and Effectiveness of Repeated Botulinum Toxin A Intracavernosal Injections in Men with Erectile Dysfunction Unresponsive to Approved Pharmacological Treatments: Real-World Observational Data. Toxins, 15(6), 382. https://doi.org/https://doi.org/10.3390/toxins15060382
Hatzimouratidis, K., & Hatzichristou, D. G. (2004). Treatment options for erectile dysfunction in patients failing oral drug therapy. EAU Update Series, 2(2), 75-83. https://doi.org/https://doi.org/10.1016/j.euus.2004.03.001
Hatzimouratidis, K., & Hatzichristou, D. G. (2005). A comparative review of the options for treatment of erectile dysfunction: which treatment for which patient? Drugs, 65, 1621-1650. https://doi.org/https://doi.org/10.2165/00003495-200565120-00003
Hatzimouratidis, K., Salonia, A., Adaikan, G., Buvat, J., Carrier, S., El-Meliegy, A., McCullough, A., Torres, L. O., & Khera, M. (2016). Pharmacotherapy for erectile dysfunction: recommendations from the Fourth International Consultation for Sexual Medicine (ICSM 2015). The journal of sexual medicine, 13(4), 465-488. https://doi.org/https://doi.org/10.1016/j.jsxm.2016.01.016
Hollenberg, P. F. (2002). Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes. Drug metabolism reviews, 34(1-2), 17-35. https://doi.org/https://doi.org/10.1081/DMR-120001387
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