https://js.donga.edu.vn/index.php/daujs <div id="text-124540630" class="text"> <p>Tạp ch&iacute; Khoa học Đại học Đ&ocirc;ng &Aacute; l&agrave; một tạp ch&iacute; trực thuộc Trường Đại học Đ&ocirc;ng &Aacute;.</p> <p>Tạp ch&iacute; được Bộ Th&ocirc;ng tin v&agrave; Truyền th&ocirc;ng cấp Giấy ph&eacute;p hoạt động cho tạp ch&iacute; in:<strong>&nbsp;Số</strong>&nbsp;<strong>625/GP-BTTTT</strong>, ng&agrave;y&nbsp;<strong>22/09/2021.</strong></p> <p>Ng&agrave;y&nbsp;<strong>28/04/2022</strong>, Tạp ch&iacute; được Cục Th&ocirc;ng tin khoa học v&agrave; C&ocirc;ng nghệ Quốc gia, Bộ Khoa học v&agrave; C&ocirc;ng nghệ cấp m&atilde; số chuẩn quốc tế ISSN (International Standard Serial Number) với d&atilde;y số ISSN:&nbsp;<strong>2815-5807.</strong></p> </div> <div id="text-3048248437" class="text"> <p>C&aacute;c lĩnh vực nhận b&agrave;i ch&iacute;nh của Tạp ch&iacute; Khoa học Đại học Đ&ocirc;ng &Aacute; bao gồm:</p> <ul> <li>Khoa học tự nhi&ecirc;n</li> <li>Khoa học kỹ thật v&agrave; c&ocirc;ng nghệ</li> <li>Khoa học y, dược</li> <li>Khoa học n&ocirc;ng nghiệp</li> <li>Khoa học x&atilde; hội</li> <li>Khoa học nh&acirc;n văn</li> </ul> </div> Trường Đại học Đông Á vi-VN Hệ thống gửi nhận bài - phản biện Tạp chí Khoa học Đại học Đông Á 2815-5807 https://js.donga.edu.vn/index.php/daujs/article/view/535 Dipeptidyl peptidase 4 (DPP4) plays a crucial role in glucose metabolism and is a validated therapeutic target for type 2 diabetes mellitus. Despite the availability of several DPP4 inhibitors, the discovery of novel scaffolds with improved safety and pharmacokinetic profiles remains an unmet need. In this study, a structure-based pharmacophore model integrating key interaction features of saxagliptin and vildagliptin was constructed and applied to screen the Enamine database, aiming to identify new chemotypes distinct from existing inhibitors. The top hits were prioritized through molecular docking, drug-likeness assessment, and ADMET prediction. Among them, compound 3 emerged as a novel lead scaffold, showing strong binding affinity (-9.5 kcal/mol) and stable interactions with critical catalytic residues, including Ser630 and Tyr547. SwissADME analysis indicated favorable oral pharmacokinetics with high gastrointestinal absorption and no BBB penetration. Toxicity prediction suggested low acute toxicity (LD₅₀ = 1500 mg/kg, Class 4), with minimal hepatic and cardiac risks. Overall, this work introduces a computationally validated pharmacophore-driven strategy to identify new DPP4 inhibitor scaffolds, providing a promising starting point for further experimental optimization. Pham Khanh Huyen Thi Nguyen Huynh Van Thi Nguyễn Tấn Khanh Copyright (c) 2025 Tạp chí Khoa học Đại học Đông Á https://creativecommons.org/licenses/by-nc-nd/4.0 2025-12-30 2025-12-30 4 4 10.59907/daujs.4.4.2025.535 https://js.donga.edu.vn/index.php/daujs/article/view/536 Biomass-derived carbon dots (BDCDs) have emerged as sustainable photoluminescent nanomaterials for sensing, bioimaging, photocatalysis, and drug delivery, offering advantages of low cost, low toxicity, and waste valorization. BDCD properties - including particle size, quantum yield, surface chemistry, and emission wavelength - are critically influenced by the synthetic route and processing conditions, rather than the type of precursor alone. This mini-review systematically compares bottom-up methods (microwave-assisted, pyrolysis, hydrothermal/solvothermal) and top-down approaches (arc discharge, laser ablation, chemical oxidation), evaluating their influence on material characteristics and functional performance. Representative examples with quantitative data illustrate how reaction parameters control structural and photophysical properties. Critical analysis reveals persistent challenges, including batch-to-batch variability, structural ambiguity (between carbon dots and carbonized polymers), energy consumption ranging from 0.5 to 50 kWh/g, and inconsistent reporting standards. The review extracts empirical design rules that link synthesis conditions to target properties, compares BDCDs with conventional fluorophores, and assesses their environmental credentials. Directions for advancing the field include the development of standardized protocols, integration with renewable energy, comprehensive toxicological evaluation, and application-driven optimization to enable the transition from laboratory proof-of-concept to scalable, reproducible BDCD technologies. Võ Châu Ngọc Anh Đỗ Mai Nguyễn Copyright (c) 2025 Tạp chí Khoa học Đại học Đông Á https://creativecommons.org/licenses/by-nc-nd/4.0 2025-12-30 2025-12-30 4 4 10.59907/daujs.4.4.2025.536 https://js.donga.edu.vn/index.php/daujs/article/view/537 The novelty of this research lies in identifying the hierarchical impact of Corporate Social Responsibility (CSR) dimensions in Vietnam. Nowadays, employees are increasingly concerned about carrying out CSR activities. Identifying and measuring the influence of CSR factors on employee satisfaction is crucial for businesses seeking to evaluate and optimize the effectiveness and quality of their implemented CSR programs. At the same time, the collected data will provide a scientific basis for businesses to build appropriate human resource policies and strategies, contributing to enhancing employee engagement and loyalty. The scope of this article will focus on evaluating the factors of CSR affecting the satisfaction of officers, officials and employees at some banks in Vietnam through 4 aspects, including: CSR in Economics, CSR in Law, CSR in Ethics, and CSR in Volunteering. Research data were collected through a survey of 500 bank employees and performed multiple linear regression analysis on SPSS 28 software. The research results show that all 4 factors have an impact on the satisfaction of officers, officials and employees arranged in ascending order as CSR in Law, CSR in Ethics, CSR in Economics and CSR in Volunteering. Specifically, the CSR in Law factor has the strongest impact, the CSR in Ethics factor has the second strongest impact, the CSR in Economics factor has the third strongest impact, and the CSR in Volunteering factor has the fourth strongest impact. A notable finding is that CSR in Law exerts the strongest influence, surpassing both Economic and Ethical factors. This reflects the unique characteristics of the Vietnamese context, where legal stability and regulatory compliance are highly prioritized by the workforce, likely due to the recent volatility and legal risks observed within the financial sector. Nam Nguyễn Hoàng Copyright (c) 2025 Tạp chí Khoa học Đại học Đông Á https://creativecommons.org/licenses/by-nc-nd/4.0 2025-12-30 2025-12-30 4 4 10.59907/daujs.4.4.2025.537 https://js.donga.edu.vn/index.php/daujs/article/view/526 This paper examines the industrialization and modernization process of South Korea from the late 19th century to the late 20th century, focusing on the historical, political, and economic drivers led by Park Chung Hee. Rooted in Confucian heritage, the Kabo reforms, and the Japanese colonial experience, South Korea developed a strong awareness of education, science, and economic management. Park Chung Hee, with his strategic vision and political organizational skills, implemented five-year economic plans, established heavy and chemical industries, building POSCO, and research institutions such as KIST/KAIST, promoted exports, and introduced a model of “national capitalism” centered on large chaebols. Consequently, South Korea transformed from a poor agrarian society into a modern industrial nation, achieving 8-10% annual growth and becoming a regional economic power. The paper highlights the roles of education, practical learning (Silhak), collaboration with Japan, and innovation in industrialization. It also draws lessons on the importance of independence, self-reliance, and strategic adaptability for developing countries seeking rapid modernization and economic development. Nguyễn Xuân Xanh Copyright (c) 2025 Tạp chí Khoa học Đại học Đông Á https://creativecommons.org/licenses/by-nc-nd/4.0 2025-12-30 2025-12-30 4 4 10.59907/daujs.4.4.2025.526 https://js.donga.edu.vn/index.php/daujs/article/view/527 This article presents an overview and assessment of the study-abroad scholarship programs implemented by the Government of the Republic of Vietnam (RVN) from the 1950s to 1975. With the goals of modernizing the nation and cultivating a highly qualified professional workforce, the RVN sent thousands of outstanding students to advanced countries—primarily the United States, France, Australia, and Canada—to pursue strategic fields such as engineering, agriculture, medicine, education, and public administration. The article analyzes the objectives, scale, organizational structure, and selection procedures of these scholarship programs, while also examining the main funding sources, including the national budget and aid from allied countries, particularly the United States. The study evaluates the achievements of the programs, such as the emergence of a Western-educated intellectual elite that contributed significantly to economic, social, and academic developments in South Vietnam. In addition to successes, the article discusses the challenges and limitations of the programs, including issues of “brain drain” when some scholarship recipients did not return, as well as disruptions caused by wartime conditions. The article concludes by offering a comprehensive evaluation of the legacy and long-term impacts of these programs on Vietnam’s human resources both before and after 1975, affirming that these initiatives represented one of the most forward-looking and consequential human-capacity development efforts undertaken by the RVN government in former South Vietnam. Nguyễn Khôi Copyright (c) 2025 Tạp chí Khoa học Đại học Đông Á https://creativecommons.org/licenses/by-nc-nd/4.0 2025-12-30 2025-12-30 4 4 10.59907/daujs.4.4.2025.527 https://js.donga.edu.vn/index.php/daujs/article/view/528 This study examines the relationship between J. R. R. Tolkien's philosophical idea that “evil cannot create, only corrupt” and the contemporary phenomenon of AI-generated content abuse. Drawing on textual analysis of The Silmarillion and The Lord of the Rings, alongside insights from ethics, media studies, and philosophy of technology, the research highlights that true creativity is inseparable from ethical responsibility, intentionality, and human experience. The findings suggest that, like Tolkien’s depiction of Melkor and Sauron - who cannot originate life but only distort existing creations - generative AI can produce outputs without genuine creative insight. When humans misuse AI to replace or replicate creative work without understanding its intrinsic value, they risk a form of “digital corruption” analogous to Tolkien’s corrupted beings. This raises serious ethical and humanistic concerns across art, literature, and knowledge production. The study concludes that AI should be treated as a tool to augment, not replace, human creativity. Safeguarding the essence of creative work requires cultivating ethical awareness, humanistic education, and policies that protect the integrity of authorship. Tolkien’s insight remains relevant today: meaningful creation is inseparable from virtue, care, and responsibility - qualities that no algorithm can inherently possess. Nguyễn Quân Copyright (c) 2025 Tạp chí Khoa học Đại học Đông Á https://creativecommons.org/licenses/by-nc-nd/4.0 2025-12-30 2025-12-30 4 4 10.59907/daujs.4.4.2025.528 https://js.donga.edu.vn/index.php/daujs/article/view/525 The Nguyễn Dynasty (1802–1945) was the last monarchical dynasty of Vietnam. This dynasty left behind a massive and majestic complex of relics in Huế city, the ancient capital of Vietnam, with many types of architecture, including citadels, palaces, temples, mausoleums of kings and royals, recognized by UNESCO as a World Cultural Heritage in 1993. This paper introduces the 7 most important mausoleums of the Nguyễn kings, currently existing in Huế city, focusing on the issues of planning ideology, architectural art and landscape value. Trần Đức Anh Sơn Copyright (c) 2025 Tạp chí Khoa học Đại học Đông Á https://creativecommons.org/licenses/by-nc-nd/4.0 2025-12-30 2025-12-30 4 4 10.59907/daujs.4.4.2025.525 https://js.donga.edu.vn/index.php/daujs/article/view/442 This article systematizes and compares the characteristics of pointed-bottom pottery from the Quynh Van culture (North Central Vietnam) with those from early pottery centers in Northeast Asia and the Russian Far East - Siberia. Pointed-bottom pottery is a representative ceramic type in hunter-gatherer cultures dating to the Late Pleistocene and Holocene, and it is widely distributed across regions such as southern China, Japan, the Korean Peninsula, and the Russian Far East - Siberia. The study focuses on the analysis of the shape, materials, manufacturing techniques, decorative patterns, and ecological contexts of pointed-bottom pottery from the Quynh Van culture. These are compared with international archaeological data in order to identify both similarities and differences. The findings indicate that Quynh Van pottery shares numerous functional and technological traits with pottery traditions from Northeast Asia and Siberia, although it appears later in the archaeological record. Based on this, the paper proposes two main hypotheses: the first posits independent technological convergence shaped by similar environmental conditions, and the second considers the possibility of technological diffusion through coastal migration networks. The study contributes to a better understanding of the role of the Quynh Van culture within the broader Asian archaeological context and provides a new perspective for interregional research on prehistoric ceramics. Bùi Xuân Tùng Chu Dinh Tuan Copyright (c) 2025 Tạp chí Khoa học Đại học Đông Á https://creativecommons.org/licenses/by-nc-nd/4.0 2025-12-30 2025-12-30 4 4 10.59907/daujs.4.4.2025.442