Dong A University Journal of Science

Computational Investigate Into The Anti-breast Cancer Potential of Panax Ginseng Via Ubiquitin-Specific Protease 46 Inhibition.

Khanh Huyen Thi Pham Khanh Huyen Thi Pham — 2025-10-01

Breast cancer is a disease with a high mortality rate in women worldwide. The rate is increasing, escalating the medical burden in developed countries as well as developing countries. Several risk factors contribute to the development of this disease, including early puberty, late menopause, postmenopausal obesity, and the use of oral contraceptives or hormone replacement therapy, all of which slightly increase the risk of breast cancer. The search for new treatments to reach the majority of patients is very necessary. Notably, by searching for the pathogenesis, many studies have shown that Ubiquitin-Specific Protease 46 is involved in the development and metastasis of breast cancer cells. This insight has prompted efforts to identify potential inhibitors with biological activity capable of targeting this enzyme. Our study has identified Aposiopolamine, a compound derived from Panax ginseng, which demonstrates strong inhibitory potential against Ubiquitin-Specific Protease 46 and exhibits favorable pharmacokinetic properties.

Enhancing the Management of Patient Safety at Tien Giang Provincial General Hospital in the 2024 - 2025 Period

Đức Luật Huỳnh — 2025-10-01

Objective: To characterize the current status of patient-safety management and to strengthen patient-safety governance at Tien Giang Provincial General Hospital during 2024 – 2025. Methods: A cross-sectional descriptive study was conducted among 300 healthcare professionals employed at the hospital. Results: Baseline (input) indicators: A positive assessment of ward-level patient safety was reported by 86,0 % of respondents; The 12-month incident-reporting rate was 30,7 %; The overall mean compliance across the 12 patient-safety culture domains was 84,4 %. Follow-up (output) indicators: The proportion rating ward-level patient safety as positive rose to 92,4 %; The 12-month medical-incident reporting rate increased to 50,2 %; Overall compliance across the 12 patient-safety culture domains improved to 90,3 %. Statistically significant associations were observed between perceived patient-safety level and job position, professional role, and degree of patient contact (p < 0,05). Incident reporting within the preceding 12 months was also significantly associated with professional role (p = 0,026). Conclusion: Healthcare staff at Tien Giang Provincial General Hospital demonstrated a high baseline compliance (84,4 %) with the 12 patient-safety culture domains. Nevertheless, to further enhance clinical service quality, the hospital should implement structured processes and strategic directions aimed at cultivating an optimal patient-safety culture.

Dementia and Associated Factors in the Elderly

Trịnh Đạt Đỗ Vũ — 2025-10-01

Introduction: Dementia is a common chronic disorder in the elderly, characterized by cognitive decline while maintaining normal consciousness. This is a noteworthy issue in the context of population aging in Vietnam, especially in Quang Ngai. Objective: To determine the prevalence of sarcopenia and its associated factors in elderly inpatients at Son Tinh District General Hospital. Methods: A cross-sectional descriptive study was conducted on 400 patients aged 60 years and older, selected entirely using the convenient sampling method. The assessment tool used was the Mini-Mental State Examination (MMSE) scale to classify the levels of cognitive impairment. Results: The prevalence of dementia in the study population was 56.2%, including mild (24.2%), moderate (25.0%), and severe cases (7.0%). Identified risk factors included advanced age (≥ 77 years, OR = 12.2), low educational attainment (OR = 4.3), lack of intellectual work (OR = 2.7), infrequent television viewing (OR = 5.5), and living alone (OR = 5.4). Discussion: The high prevalence of dementia observed in this study suggests that it is becoming a significant health burden among the elderly in Son Tinh. Risk factors such as age, education level, and social interaction indicate that improving education and promoting social activities could be important interventions to mitigate risks. Additionally, health policies and intervention programs focusing on early screening and raising community awareness of dementia are necessary. Conclusion: The findings indicate that dementia is a significant health burden among the elderly in the locality. Developing intervention programs such as early screening, raising community awareness, and improving living environments is essential to reduce the impact of dementia and enhance the quality of life for the elderly.

A Geometric Characterization of Extremal Sets in a Hemi-Sphere of S^∞.

Văn An Nguyễn — 2025-10-01

In the paper we give a geometric characterization of extremal sets contained in a hemi-sphere of S∞ that generalizes previously known results with respect to the classical Jung theorem.

Assessing the Situation of Social Media Addiction among First-year Students at the Ho Chi Minh City University of the Physical Education and Sport

Thị Bích Thủy Tô — 2025-10-01

In Vietnam, research projects assessing the situation of social media addiction in students mainly use other scales and research samples from universities with majors other than physical education. This article applies a cross-sectional descriptive study to assess the situation of social media addiction on 302 first-year students at the Ho Chi Minh City University of Physical Education and Sport. The study was conducted through a survey questionnaire based on the Bergen Social Media Addiction Scale (BSMAS). The research sample is first-year students, who have just entered university, started an independent life and are less supervised by adults, have easy access to different forms of entertainment, especially on social media. Survey results showed that, the mean BSMAS score was 16.01 (SD = 4.80). The percentage of students having signs of social media addiction (BSMAS score ≥ 19) accounted for 22.85%. Male students tend to be more addicted to social media than female students, with the rate of social media addiction in the male group being 16.23% and in the female group being 6.62%.

Euthanasia in Japan as a New Human Right: A Perspective of Expert Viewpoints

Ly Tuan Phan — 2025-10-01

Respect for fundamental human rights is one of the three crucial principles enshrined in Japan's current Constitution, alongside popular sovereignty and pacifism. Accordingly, human rights are understood as natural rights, recognized, guaranteed, and protected by the State. The right to life is a fundamental right recognized and protected by the Japanese Constitution under Article 13. However, the right to die, or the right to euthanasia, is often considered antithetical to the right to life and has not yet been recognized or protected by the Japanese State. Japanese society has witnessed several incidents related to the right to euthanasia, which have sparked debates on whether Japan should legalize it and consider it a fundamental right deserving protection. This article analyzes the right to euthanasia in Japan by examining expert Japanese perspectives from a human rights viewpoint, utilizing synthesis and content analysis methods. The study aims to document theoretical issues concerning fundamental human rights in Japan, systematically analyze Japanese experts' views, and discuss various aspects related to the right to euthanasia—an emerging fundamental human right.

Reviewing the Journey of Tây Sơn Nguyễn Văn Huệ to China and the Theory of the Pretender King.

THÀNH TƯ GIAI THÀNH TƯ GIAI — 2025-10-01

Nguyễn Văn Huệ was the first and also the only Vietnamese monarch personally recorded in Chinese history as having traveled to China for a court audience. However, due to discrepancies between Chinese and non-Chinese sources, scholars have been divided into two opposing schools of thought: the “real king” theory and the “pretender king” theory. This study revisits several early historical records concerning the theory of the pretender king, examining how this interpretation has been constructed and developed in scholarly writings-starting from the idea that the impersonator was a military general or subordinate official, and later evolving into claims that he was a relative of the monarch. Such transformations reflect the way historical sources have been understood and reinterpreted. The study argues that Nguyễn Văn Huệ indeed sent someone to impersonate him in China, but that impersonator was in fact a military general or an official. Both Nguyễn Quang Thực and Nguyễn Văn Trị were simply different names used for the same impostor.